Specialties
Diavis
Highlights
- Provides nutrition support for those with diabetes mellitus or those highly at risk for this condition
- Supports visual and whole body health
- Based on the latest scientific research
- DiaVis delivers nutrients that:
- help combat oxidative stress and inflammation
- can be marginally deficient and that play a role in normal glucose metabolism
- may be affected by the use of diabetes-related medications
- support retinal vessel health
- promote a healthy equilibrium of fluids in the eye
- are associated with a reduced risk of developing diabetes
- Made from premium ingredients and manufactured according to the highest quality standards
- Two capsules per day
Research
- Quercetin (110 mg)
Quercetin, a dietary flavonoid, has been shown experimentally to inhibit tyrosine kinase, an enzyme which mediates vascular endothelial growth factor (VEGF). VEGF induces vascular permeability. Quercetin has also demonstrated protection of retinal pigment epithelial and cortical cells during oxidative stress in vitro. Several large-scale epidemiologic studies report clear associations between dietary quercetin and lower risk of mortality from CHD and stroke. Recent work suggests that quercetin accumulates in atherosclerotic lesions where it down-regulates expression of scavenger receptors for oxidized LDL in macrophages. In a clinical trial, diabetics fed a diet high in quercetin exhibited significantly less DNA damage in lymphocytes compared to a diet low in quercetin. DiaVis provides quercetin at the level investigated in that clinical trial. - Pine Bark Polyphenols (125 mg) - Including 20 mg Pycnogenol®
Pine bark is a concentrated source of polyphenols, which are found in grapes and other dietary sources. Polyphenols exhibit strong antioxidant action and act as natural anti-inflammatories, possibly by inhibiting pro-inflammatory gene expression. They selectively bind to collagen and elastin, strengthening blood vessel walls and improving capillary resistance capillaries. Finally, they aid in the production of the endothelial vasodilator nitric oxide.
Pine bark extract (Pycnogenol®) has been tested in about 1200 people with retinopathy and diabetic retinopathy in open and controlled trials, with reported results generally supporting a beneficial delay of progression. Preliminary studies report that supplemental Pycnogenol® pine bark extract improves microcirculation and symptoms in patients with diabetes, neuropathy, and edema. In a double-blind study in type 2 diabetics on ACE inhibitors, researchers report that 3 months of supplementation lowered the use of this medication by 50% on average. - Alpha Lipoic Acid (300 mg)
Alpha lipoic acid is a fat and water soluble antioxidant that plays a crucial role in the energy-producing mitochondria of cells. It regenerates other antioxidants including glutathione, a key antioxidant enzyme in eye tissue. In animal models of diabetic retinopathy, alpha lipoic acid has shown a protective effect against microvascular damage. Alpha lipoic acid is also concentrated in nerve cells, and numerous well-controlled clinical trials report that this antioxidant reduces symptoms of diabetic sensorimotor polyneuropathy. DiaVis delivers high potency alpha lipoic acid. - Beta-Carotene (equivalent to 500 IU), Vitamins A (500 IU), C (250 mg) and E (60 IU)
People with diabetes often have increased oxidative stress - a factor in the development of many diabetic complications. Both types 1 and 2, as well as those with retinopathy, can have lower blood antioxidant levels. DiaVis includes antioxidant beta-carotene because it has been reported to be significantly lower in diabetic patients than controls. Some pre-formed vitamin A is also provided, as the bioavailability of dietary beta-carotene has been found to be lower and more variable than previously believed, particularly in women. Vitamin C is highly concentrated in the eye's aqueous humor and in nerve cells, and higher blood levels are reportedly linked with a lower risk of developing diabetes in people followed long term. In one study, long term use of C, E and / or a multinutrient supplement was associated with a reduced risk of retinopathy. The level of vitamin C contained in DiaVis is within the range estimated to saturate eye tissues.
The fat soluble antioxidant, vitamin E, is provided to ensure adequacy of the full antioxidant team. Evidence suggests that antioxidants with different activities and redox potentials work in a synergistic network to help combat oxidative stress. Overall, research indicates that levels of vitamin E in line with amounts obtainable from foods are sufficient to provide protective antioxidant effects; hence DiaVis offers a prudent level of natural source alpha and gamma vitamin E. - Vitamin D (800 IU)
Low vitamin D status is more common in type 2 than type 1, and hypovitaminosis D is highly prevalent in type 2 adults. Both vitamin D & calcium insufficiency may negatively influence blood glucose levels. One large prospective study found that levels of vitamin D greater than 800 IU are significantly better than 400 IU in reducing type 2 diabetes risk. Vitamin D exerts anti-inflammatory action by decreasing production of pro-inflammatory interleukins. In addition, preliminary evidence has shown that vitamin D intake reduces C-reactive protein (CRP), a marker of systemic inflammation. In type 2 diabetes, higher circulating levels of vitamin D are also reported to be strongly and independently associated with increased thickening of the carotid artery wall, a measure for assessing atherosclerotic cardiovascular disease. Experts calculate that 1,000 IU vitamin D daily is required to bring half the population into the range of serum D associated with multiple health endpoints, while risk assessments conclude that this is a safe supplemental level. DiaVis supplies 800 IU daily, to accommodate any additional vitamin D an individual may be ingesting from a calcium or other multi supplement. - B-Vitamins: Thiamine (B1, 18 mg), riboflavin (B2, 3.4 mg), niacinamide (B3, 20 mg ), pyridoxine (B6 10 mg), folic acid (200 mcg), cobalmin (B12, 50 mcg), & biotin (200 mcg)
Recent research reports that type 1 & 2 diabetics excrete more B1, & have low plasma levels of this vitamin. B1 plays a role in glucose metabolism, and inadequate levels increase risk of kidney, nerve and eye complications in animal models of diabetes. Vitamins B1 and B2 have been linked to decreased cataract risk. Low plasma B6 has been observed in those with types 1 and 2 diabetes, and B6 status declines with age. Older people in general are at high risk of low blood levels of B12, a vitamin critical to proper nerve function. Folic acid , B6 and B12 also help maintain healthy homocysteine levels. Elevated homocysteine levels have been associated with the prevalence and the severity of kidney failure in diabetes patients. Vitreous homocysteine levels have also been shown to be elevated in patients with proliferative diabetic retinopathy compared to nondiabetic patients with nonproliferative ocular diseases. DiaVis furnishes a full array of B vitamins to ensure adequacy and maintain a balance between them. - Minerals: Magnesium (200 mg), Chromium (200 mcg), Zinc (7.5 mg)
It is well established that diabetics with poor glucose control are often low in magnesium, a mineral involved in maintaining normal endothelial function and insulin sensitivity. In an analysis of the NHANES survey, magnesium supplementation was associated with lower levels of the inflammatory biomarker CRP. Population health studies consistently link adequate intakes of this mineral with a reduced chance of developing hypertension, diabetes and the metabolic syndrome. A meta-analysis reports that for every 100 mg increase in magnesium intake, the observed risk of developing type 2 declined by 15%. DiaVis delivers concentrated and bioavailable forms of magnesium at a well tolerated level.
Zinc plays a vital role in the production, storage and secretion of insulin. It is also a co-factor for the antioxidant enzyme superoxide dismutase present in eye tissues. Increased insulin secretion is associated with a greater urinary zinc loss in type 1 & 2 diabetics, thus DiaVis includes a modest level of zinc to offset any increased urinary excretion of this mineral.
The role of chromium in the body is to facilitate the action of insulin. Some trials examining whether chromium can decrease fasting blood glucose, insulin levels, and HbA1c in diabetics report benefit; others do not. Evidence indicates that this trace mineral is of benefit primarily to those low in chromium and with impaired glucose. DiaVis provides a maintenance dose of chromium in the most-studied form, chromium picolinate. - FloraGLO Lutein (2 mg) Zeaxanthin (120 mcg)
Lutein and zeaxanthin compose the macular pigment of the retina, where they filter blue (visible) light that can induce photo-oxidative stress. A number of population health studies link higher intakes of these carotenoids with a reduced risk of cataract and macular degeneration. Findings from one study suggest that higher levels of plasma lutein and zeaxanthin may be protective against early atherosclerosis. In an animal model of diabetes, lutein decreased oxidative stress in acute retinal ischemia. The amount of lutein contained in DiaVis doubles the average US dietary intake of this carotenoid.









| Murfreesboro, TN 37129 | phone: (615) 904-9024 | fax: (615) 904-0337